Estádio: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Dean Hood
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | W | 10-28 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | W | 32-31 |
| NCAAF | 2021/03/07 20:00 | Murray State v SE Missouri St | W | 24-21 |
| NCAAF | 2019/11/23 19:00 | Murray State v SE Missouri St | L | 24-31 |
| NCAAF FCS | 2018/11/10 17:00 | SE Missouri St v Murray State | W | 38-40 |
| NCAAF | 2017/11/18 19:00 | SE Missouri St v Murray State | L | 21-10 |
| NCAAF | 2022/11/12 19:00 | Robert Morris v Murray State | W | 9-27 |
| NCAAF | 2022/10/29 19:00 | Tennessee State v Murray State | W | 3-19 |
| NCAAF | 2022/10/22 18:00 | Murray State v Lindenwood | L | 18-33 |
| NCAAF | 2022/10/15 20:00 | Murray State v Austin Peay | L | 17-52 |
| NCAAF | 2022/10/08 19:00 | Tennessee Martin v Murray State | L | 45-16 |
| NCAAF | 2022/10/01 23:00 | Murray State v SE Louisiana | L | 14-48 |
| NCAAF | 2022/09/24 21:00 | Eastern Illinois v Murray State | L | 35-21 |
| NCAAF | 2022/09/17 18:00 | Murray State v Ball State | L | 0-31 |
| NCAAF | 2022/11/12 20:00 | SE Missouri St v Eastern Illinois | W | 31-7 |
| NCAAF | 2022/11/05 22:00 | SE Missouri St v Tennessee State | W | 42-0 |
| NCAAF | 2022/10/29 18:00 | Eastern Kentucky v SE Missouri St | L | 28-23 |
| NCAAF | 2022/10/22 18:00 | SE Missouri St v Northwestern State | W | 51-16 |
| NCAAF | 2022/10/08 19:00 | Tennessee Tech v SE Missouri St | W | 20-34 |
| NCAAF | 2022/10/01 18:00 | SE Missouri St v Lindenwood | W | 49-28 |
| NCAAF | 2022/09/24 19:00 | Central Arkansas v SE Missouri St | W | 27-35 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | W | 16-42 |