[3] Santos Laguna 1-2 Club León [16] 2021-03-22 01:06
Estádio: Estádio Corona Round: 12
Juiz: Oscar Mejia Garcia Home Manager: Guillermo Almada Away Manager: Ignacio Ambriz
Head to Head
| México - Liga MX | 2020/11/03 03:00 | Club León v Santos Laguna | L | 2-1 |
| México - Liga MX | 2020/01/20 00:45 | Santos Laguna v Club León | W | 3-2 |
| México - Liga MX | 2019/08/29 00:00 | Club León v Santos Laguna | D | 2-2 |
| México - Liga MX | 2019/03/03 01:00 | Club León v Santos Laguna | L | 3-0 |
| México - Liga MX | 2018/09/16 21:00 | Santos Laguna v Club León | W | 3-0 |
| México - Liga MX | 2018/02/15 01:00 | Santos Laguna v Club León | W | 5-1 |
| México - Liga MX | 2017/08/27 00:06 | Club León v Santos Laguna | W | 1-2 |
| México - Liga MX | 2017/02/19 01:06 | Club León v Santos Laguna | D | 2-2 |
Home History
| México - Liga MX | 2021/03/14 03:05 | Tijuana v Santos Laguna | W | 0-1 |
| México - Liga MX | 2021/03/08 01:06 | Santos Laguna v Necaxa | W | 3-1 |
| México - Liga MX | 2021/03/05 03:00 | Pumas v Santos Laguna | L | 1-0 |
| México - Liga MX | 2021/03/01 01:06 | Santos Laguna v Juárez FC | W | 3-2 |
| México - Liga MX | 2021/02/19 03:00 | Atlético San Luís v Santos Laguna | L | 1-0 |
| México - Liga MX | 2021/02/15 01:06 | Santos Laguna v Monterrey | W | 1-0 |
| México - Liga MX | 2021/02/06 23:00 | Atlas v Santos Laguna | D | 1-1 |
| México - Liga MX | 2021/02/01 01:06 | Santos Laguna v Club América | D | 1-1 |
Away History
| México - Liga MX | 2021/03/16 03:00 | Club León v Necaxa | W | 3-1 |
| México - Liga MX | 2021/03/11 03:00 | Monterrey v Club León | D | 1-1 |
| México - Liga MX | 2021/03/07 01:00 | Club América v Club León | L | 2-1 |
| México - Liga MX | 2021/03/03 03:00 | Club León v Puebla | L | 1-2 |
| México - Liga MX | 2021/02/28 03:00 | Club León v Cruz Azul | L | 0-1 |
| México - Liga MX | 2021/02/21 18:00 | Pumas v Club León | W | 0-1 |
| México - Liga MX | 2021/02/13 03:06 | Tijuana v Club León | L | 2-0 |
| México - Liga MX | 2021/02/09 03:00 | Club León v Chivas Guadalajara | L | 1-3 |
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