[7] Santos Laguna 1-1 Cruz Azul [16] 2021-08-01 23:00
Estádio: Estádio Corona Round: 2
Juiz: Jorge Isaac Rojas Castillo Home Manager: Guillermo Almada Away Manager: Juan Maximo Reynoso
Head to Head
| México - Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |
| México - Liga MX | 2021/05/28 02:00 | Santos Laguna v Cruz Azul | L | 0-1 |
| México - Liga MX | 2021/01/11 01:06 | Santos Laguna v Cruz Azul | W | 1-0 |
| México - Liga MX | 2020/07/26 02:00 | Cruz Azul v Santos Laguna | L | 2-0 |
| México - Liga MX | 2020/01/25 23:00 | Cruz Azul v Santos Laguna | L | 3-0 |
| México - Liga MX | 2019/11/11 00:45 | Santos Laguna v Cruz Azul | W | 3-1 |
| México - Liga MX | 2019/02/16 23:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| México - Liga MX | 2018/08/26 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
Home History
| México - Liga MX | 2021/07/24 00:00 | Necaxa v Santos Laguna | W | 0-3 |
| Europa - Amigáveis | 2021/07/05 00:30 | Club América v Santos Laguna | L | 1-0 |
| México - Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |
| México - Liga MX | 2021/05/28 02:00 | Santos Laguna v Cruz Azul | L | 0-1 |
| México - Liga MX | 2021/05/24 00:00 | Puebla v Santos Laguna | L | 1-0 |
| México - Liga MX | 2021/05/21 02:00 | Santos Laguna v Puebla | W | 3-0 |
| México - Liga MX | 2021/05/16 23:00 | Monterrey v Santos Laguna | D | 1-1 |
| México - Liga MX | 2021/05/14 02:05 | Santos Laguna v Monterrey | W | 2-1 |
Away History
| México - Liga MX | 2021/07/27 01:00 | Cruz Azul v Mazatlán FC | L | 0-2 |
| México - Campeón de Campeones | 2021/07/18 23:30 | Club León v Cruz Azul | W | 1-2 |
| México - Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |
| México - Liga MX | 2021/05/28 02:00 | Santos Laguna v Cruz Azul | W | 0-1 |
| México - Liga MX | 2021/05/23 01:00 | Cruz Azul v Pachuca | W | 1-0 |
| México - Liga MX | 2021/05/20 01:30 | Pachuca v Cruz Azul | D | 0-0 |
| México - Liga MX | 2021/05/16 01:05 | Cruz Azul v Toluca | W | 3-1 |
| México - Liga MX | 2021/05/13 00:00 | Toluca v Cruz Azul | L | 2-1 |
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