Estádio: Estádio Robert W. Plaster Round: 1
Home Manager: Bobby Petrino Away Manager: Bob Nielson
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | L | 27-24 |
| NCAAF | 2019/10/12 19:00 | South Dakota v Missouri St | W | 45-10 |
| NCAAF | 2018/10/06 19:00 | Missouri St v South Dakota | W | 28-35 |
| NCAAF | 2021/09/19 00:00 | South Dakota v Cal Poly | W | 48-14 |
| NCAAF | 2021/09/11 18:00 | Northern Arizona v South Dakota | W | 7-34 |
| NCAAF | 2021/09/04 00:00 | South Dakota v Kansas | L | 14-17 |
| NCAAF | 2021/03/20 16:00 | South Dakota v Youngstown State | L | 10-28 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | L | 27-24 |
| NCAAF | 2021/03/04 23:00 | South Dakota v North Dakota | L | 10-21 |
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | W | 27-20 |
| NCAAF | 2019/11/23 20:00 | South Dakota State v South Dakota | W | 21-24 |
| NCAAF | 2021/09/12 00:00 | Central Arkansas v Missouri St | W | 34-43 |
| NCAAF | 2021/09/04 23:00 | Missouri St v Oklahoma State | L | 16-23 |
| NCAAF | 2021/04/24 20:00 | Missouri St v North Dakota | L | 10-44 |
| NCAAF | 2021/04/10 19:00 | Youngstown State v Missouri St | W | 10-21 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | W | 27-30 |
| NCAAF | 2021/03/20 21:00 | Missouri St v Northern Iowa | W | 13-6 |
| NCAAF | 2021/03/13 19:00 | Missouri St v South Dakota | W | 27-24 |
| NCAAF | 2021/03/06 20:00 | North Dakota State v Missouri St | L | 25-0 |