Estádio: Estádio Robert W. Plaster Round: 1
Home Manager: Bobby Petrino Away Manager: Jason Simpson
| NCAAF | 2021/11/20 19:00 | Tennessee Martin v SE Missouri St | L | 14-31 |
| NCAAF | 2021/11/13 19:30 | Tennessee Martin v Tennessee Tech | W | 42-3 |
| NCAAF | 2021/11/06 19:00 | Tennessee State v Tennessee Martin | W | 20-41 |
| NCAAF | 2021/10/30 19:00 | Austin Peay v Tennessee Martin | W | 16-17 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | W | 30-38 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | W | 28-17 |
| NCAAF | 2021/10/09 19:00 | Murray State v Tennessee Martin | W | 24-48 |
| NCAAF | 2021/09/25 20:00 | Tennessee Martin v Jacksonville State | W | 34-31 |
| NCAAF | 2021/11/21 02:00 | Missouri St v Utah Tech | W | 55-24 |
| NCAAF | 2021/11/13 20:00 | Northern Iowa v Missouri St | W | 27-34 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | W | 38-28 |
| NCAAF | 2021/10/30 19:00 | North Dakota v Missouri St | W | 28-32 |
| NCAAF | 2021/10/23 19:30 | Missouri St v North Dakota State | L | 20-27 |
| NCAAF | 2021/10/16 19:00 | Indiana State v Missouri St | W | 7-37 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | L | 33-41 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | W | 41-20 |