[16] Pumas 1-5 Santos Laguna [6] 2022-08-21 17:00
Estádio: Estádio Olímpico Universitário Round: 10
Juiz: Marco Antonio Ortiz Nava Home Manager: Andrés Lillini Away Manager: Eduardo Fentanes
Head to Head
| México - Liga MX | 2022/03/03 03:00 | Santos Laguna v Pumas | L | 3-2 |
| México - Liga MX | 2021/11/05 01:00 | Pumas v Santos Laguna | L | 0-3 |
| México - Liga MX | 2021/03/05 03:00 | Pumas v Santos Laguna | W | 1-0 |
| México - Liga MX | 2020/09/10 02:06 | Santos Laguna v Pumas | W | 1-2 |
| México - Liga MX | 2020/02/02 03:00 | Santos Laguna v Pumas | D | 1-1 |
| Taça do México | 2020/01/30 01:00 | Pumas v Santos Laguna | W | 2-1 |
| Taça do México | 2020/01/23 03:00 | Santos Laguna v Pumas | L | 4-2 |
| México - Liga MX | 2019/09/29 17:00 | Pumas v Santos Laguna | W | 2-0 |
Home History
| México - Liga MX | 2022/08/19 02:05 | Atlético San Luís v Pumas | L | 3-2 |
| México - Liga MX | 2022/08/14 00:05 | Pumas v Club América | L | 0-3 |
| Europa - Amigáveis | 2022/08/07 18:00 | Barcelona v Pumas | L | 6-0 |
| México - Liga MX | 2022/07/31 17:00 | Pumas v Monterrey | D | 1-1 |
| México - Liga MX | 2022/07/28 02:05 | Pumas v Mazatlán FC | D | 1-1 |
| México - Liga MX | 2022/07/25 00:00 | Pachuca v Pumas | D | 0-0 |
| México - Liga MX | 2022/07/17 17:00 | Pumas v Necaxa | W | 1-0 |
| Mundo - Amigáveis de Clubes | 2022/07/14 00:00 | Pumas v Celta de Vigo | D | 1-1 |
Away History
| México - Liga MX | 2022/08/19 00:00 | Santos Laguna v Club León | W | 2-1 |
| México - Liga MX | 2022/08/15 00:05 | Tigres UANL v Santos Laguna | L | 2-0 |
| México - Liga MX | 2022/08/07 02:05 | Santos Laguna v Cruz Azul | W | 4-0 |
| México - Liga MX | 2022/08/01 00:05 | Santos Laguna v Atlas | W | 1-0 |
| México - Liga MX | 2022/07/23 22:00 | Toluca v Santos Laguna | L | 2-1 |
| México - Liga MX | 2022/07/17 00:05 | Santos Laguna v Chivas Guadalajara | D | 1-1 |
| México - Liga MX | 2022/07/09 02:05 | Puebla v Santos Laguna | L | 1-0 |
| México - Liga MX | 2022/07/04 00:05 | Santos Laguna v Monterrey | W | 4-3 |
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