Head to Head
| NFL | 2021/09/12 17:00 | SF 49ers v DET Lions | L | 41-33 |
| NFL | 2018/09/16 20:05 | DET Lions v SF 49ers | L | 27-30 |
| NFL | 2015/12/27 18:00 | DET Lions v SF 49ers | W | 32-17 |
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| NFL | 2021/09/12 17:00 | SF 49ers v DET Lions | L | 41-33 |
| NFL | 2018/09/16 20:05 | DET Lions v SF 49ers | L | 27-30 |
| NFL | 2015/12/27 18:00 | DET Lions v SF 49ers | W | 32-17 |