| WTA - Lleida | 05/01 08:00 | 25 | [237] Despina Papamichail v Magdalena Frech [51] | 2-6,4-6 | |
| WTA - Lleida | 04/30 10:25 | 14 | [237] Despina Papamichail v Yvonne Cavalle-Reimers [293] | 6-4,6-0 | |
| ITF - W75 Chiasso | 04/17 12:30 | 25 | [235] Despina Papamichail v Maria Sara Popa [432] | 7-5,5-7,6-7 | |
| Billie Jean King Cup | 04/09 10:00 | 1 | [111] Aleksandra Krunic v Despina Papamichail [235] | 6-0,6-3 | |
| Billie Jean King Cup | 04/08 09:50 | 1 | [469] Kajsa Rinaldo Persson v Despina Papamichail [235] | 4-6,4-6 | |
| ITF - W35 Santa Margherita | 04/03 07:25 | 25 | [245] Despina Papamichail v Diletta Cherubini [412] | 2-6,7-6,4-6 | |
| ITF - W35 Terrassa | 03/29 09:30 | 28 | [260] Despina Papamichail v Lois Boisson [293] | 3-6,6-0,1-6 | |
| ITF - W35 Terrassa | 03/28 09:00 | 27 | [467] Caijsa W Hennemann v Despina Papamichail [260] | 1-6,6-3,4-6 | |
| ITF - W35 Terrassa | 03/27 08:55 | 26 | [385] Ilona G Ghioroaie v Despina Papamichail [260] | 4-6,5-7 | |
| ITF - W35 Terrassa | 03/26 14:35 | 25 | Sara Dols v Despina Papamichail | 2-6,3-6 | |
| ITF - W35 Alaminos-Larnaca | 03/24 09:00 | 29 | [293] Lois Boisson v Despina Papamichail [260] | 6-2,6-0 | |
| ITF - W35 Alaminos-Larnaca | 03/23 08:00 | 28 | [260] Despina Papamichail v Deborah Chiesa [460] | 4-6,6-3,6-3 | |
| ITF - W35 Alaminos-Larnaca | 03/22 08:00 | 27 | [214] Andreea Mitu v Despina Papamichail [260] | 2-6,0-6 | |
| ITF - W35 Alaminos-Larnaca | 03/21 07:30 | 26 | [260] Despina Papamichail v Tena Lukas [203] | 4-6,6-2,6-1 | |
| ITF - W35 Alaminos-Larnaca | 03/20 09:50 | 25 | [370] Julia Middendorf v Despina Papamichail [260] | 1-6,3-6 | |
| ITF - W35 Alaminos-Larnaca | 03/12 12:05 | 25 | [181] Noma Noha Akugue v Despina Papamichail [267] | 7-5,3-6,6-1 | |
| WTA - San Diego | 02/24 23:20 | 14 | [118] Mai Hontama v Despina Papamichail [254] | 6-3,6-4 | |
| ITF - W50 Cidade do México | 02/20 19:40 | 25 | [254] Despina Papamichail v Victoria Hu [329] | 1-6,7-5,4-6 | |
| ITF - W50 Morelia | 02/14 16:55 | 26 | [146] Rebecca Marino v Despina Papamichail [250] | 6-2,6-3 | |
| ITF - W50 Morelia | 02/13 17:00 | 25 | [250] Despina Papamichail v Elvina Kalieva [226] | 7-5,4-6,6-4 | |
| WTA - Abu Dabi | 02/03 08:25 | 14 | [229] Despina Papamichail v Danielle Collins [69] | 2-6,3-6 | |
| Open da Austrália - Feminino | 01/10 01:35 | 14 | [177] Raluka Serban v Despina Papamichail [219] | 7-5,6-2 | |
| WTA - Montevideo | 12/07 21:45 | 26 | [94] Diane Parry v Despina Papamichail [221] | 6-1,6-2 | |
| WTA - Montevideo | 12/05 16:40 | 25 | [221] Despina Papamichail v Victoria Hu [332] | 6-4,6-2 | |
| WTA - Buenos Aires | 11/27 15:25 | 25 | [222] Despina Papamichail v Jamie Loeb [302] | 3-6,2-6 | |
| WTA - Florianópolis | 11/22 15:00 | 26 | [224] Despina Papamichail v Renata Zarazua [151] | 4-6,2-6 | |
| WTA - Florianópolis | 11/20 15:00 | 25 | [156] Julia Riera v Despina Papamichail [224] | 4-6,6-7 | |
| WTA - Colina | 11/15 16:20 | 26 | [131] Leolia Jeanjean v Despina Papamichail [228] | 2-6,6-4,6-2 | |
| WTA - Colina | 11/13 18:15 | 25 | [212] Solana Sierra v Despina Papamichail [228] | 3-6,2-6 | |
| ITF - W100 Les Franqueses | 10/25 11:20 | 25 | Nahia Berecoechea v Despina Papamichail | 1-6,6-2,6-2 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.