| ITF - W40 Cidade do México | 02/01 17:15 | 26 | [373] Jana Kolodynska v Despina Papamichail [151] | 6-2,3-6,6-7 | |
| ITF - W40 Cidade do México | 01/31 20:20 | 25 | Mao Mushika v Despina Papamichail | 2-6,6-4,2-6 | |
| ITF - W60 Sunderland | 01/26 10:00 | 26 | [157] Despina Papamichail v Magali Kempen [211] | 4-6,0-6 | |
| ITF - W60 Sunderland | 01/24 10:00 | 25 | [157] Despina Papamichail v Lena Papadakis [255] | 6-4,7-6 | |
| Open da Austrália - Feminino | 01/11 04:45 | 15 | [158] Despina Papamichail v Olga Danilovic [153] | 3-6,1-6 | |
| Open da Austrália - Feminino | 01/10 02:05 | 14 | [111] Reka-Luca Jani v Despina Papamichail [158] | 1-6,0-6 | |
| United Cup - Feminino | 01/07 08:50 | 28 | [158] Despina Papamichail v Lucia Bronzetti [54] | Cancelled | |
| United Cup - Feminino | 01/04 04:30 | 19 | [158] Despina Papamichail v Donna Vekic [67] | 2-6,0-6 | |
| United Cup - Feminino | 01/02 04:00 | - | [158] Despina Papamichail v Alison Van Uytvanck [72] | 5-7,6-2,3-6 | |
| United Cup - Feminino | 12/29 04:00 | - | [158] Despina Papamichail v Isabella Shinikova [381] | 3-6,6-4,6-1 | |
| ITF - W80 Valência | 11/23 10:20 | 25 | [159] Despina P'michail v Sada Nahimana [265] | 4-6,3-6 | |
| ITF - W80 Madrid | 11/16 10:25 | 25 | [155] Despina Papamichail v Marie Benoit [279] | 3-6,6-7 | |
| WTA - Colina | 11/10 15:00 | 26 | [129] Victoria Jimenez Kasintseva v Despina Papamichail [156] | 6-1,6-2 | |
| WTA - Colina | 11/08 16:25 | 25 | [156] Despina Papamichail v Darya Astakhova [221] | 6-3,6-3 | |
| ITF - W60 Barranquilla | 11/02 17:40 | 25 | Despina Papamichail v Raveena Kingsley | 3-6,6-3,2-6 | |
| ITF - W60 Hamburgo | 10/20 14:25 | 26 | [404] Julia Middendorf v Despina Papamichail [143] | 7-6,3-6,6-4 | |
| ITF - W60 Hamburgo | 10/19 08:00 | 25 | [390] Veronika Erjavec v Despina Papamichail [143] | 6-3,2-6,3-6 | |
| ITF - W60 Monastir | 10/15 11:55 | 28 | [136] Kristina Mladenovic v Despina Papamichail [152] | 6-2,6-4 | |
| ITF - W60 Monastir | 10/14 09:00 | 27 | [280] Weronika Falkowska v Despina Papamichail [152] | 3-6,6-1,2-6 | |
| ITF - W60 Monastir | 10/13 11:00 | 26 | [237] Isabella Shinikova v Despina Papamichail [152] | 6-3,3-6,6-7 | |
| ITF - W60 Monastir | 10/12 12:15 | 25 | [121] Estelle Cascino v Despina Papamichail [152] | 1-6,3-6 | |
| WTA - Monastir | 10/05 17:00 | 26 | [175] Despina Papamichail v Elise Mertens [42] | 7-5,1-6,2-6 | |
| WTA - Monastir | 10/03 10:00 | 25 | [64] Lin Zhu v Despina Papamichail [175] | 6-1,6-7,0-6 | |
| WTA - Monastir | 10/02 09:00 | 19 | [130] Kristina Mladenovic v Despina Papamichail [175] | 6-2,2-6,4-6 | |
| WTA - Monastir | 10/01 11:50 | 14 | [432] Ines Ibbou v Despina Papamichail [175] | 3-6,2-6 | |
| WTA - Tóquio | 09/21 02:00 | 26 | [213] Despina Papamichail v Garbine Muguruza [12] | 4-6,2-6 | |
| WTA - Tóquio | 09/19 11:20 | 25 | [328] Xiaodi You v Despina Papamichail [213] | 4-6,2-6 | |
| WTA - Tóquio | 09/18 02:00 | 19 | [197] Despina Papamichail v Himeno Sakatsume [357] | 6-2,6-4 | |
| WTA - Tóquio | 09/17 02:30 | 14 | [197] Despina Papamichail v Erika Sema [426] | 6-4,4-6,6-4 | |
| WTA - Chennai | 09/13 13:10 | 25 | [142] Oksana Selekhmeteva v Despina Papamichail [197] | 6-3,6-1 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.